Reconstructing human skin equivalents on fibrin-based dermal matrix
نویسندگان
چکیده
منابع مشابه
Tissue Engineered Human Skin Equivalents
Human skin not only serves as an important barrier against the penetration of exogenous substances into the body, but also provides a potential avenue for the transport of functional active drugs/reagents/ingredients into the skin (topical delivery) and/or the body (transdermal delivery). In the past three decades, research and development in human skin equivalents have advanced in parallel wit...
متن کاملSelf organization of Fibroblasts and Keratinocytes in morphogenesis of dermal-epidermal junction in human skin equivalents
Introduction Dermal epidermal junction (DEJ) is a complex macromolecular structure which establishes the boundary between two major skin compartments, epidermis and dermis and the cellular components of these layers play a major role in its organization (1). We are interested in the structural and functional analysis of the epidermis formed in human skin equivalent (HSE) models that uses co-cul...
متن کاملInduction of dermal collagenesis, angiogenesis, and adipogenesis in human skin by injection of platelet-rich fibrin matrix.
OBJECTIVE To evaluate the histological changes induced in human skin by injection of autologous platelet-rich fibrin matrix (PRFM). METHODS Four healthy adult volunteers were included in the study. Platelet-rich fibrin matrix was prepared from 9 mL of autologous blood using a proprietary system (Selphyl; Aesthetic Factors, Wayne, New Jersey) and injected into the deep dermis and immediate sub...
متن کاملEvaluation of 3D-human skin equivalents for assessment of human dermal absorption of some brominated flame retardants.
Ethical and technical difficulties inherent to studies in human tissues are impeding assessment of the dermal bioavailability of brominated flame retardants (BFRs). This is further complicated by increasing restrictions on the use of animals in toxicity testing, and the uncertainties associated with extrapolating data from animal studies to humans due to inter-species variations. To overcome th...
متن کاملElevated Matrix Metalloproteinases and Collagen Fragmentation in Photodamaged Human Skin: Impact of Altered Extracellular Matrix Microenvironment on Dermal Fibroblast Function
Exposure of the human skin to acute solar ultraviolet (UV) irradiation induces several members of the matrix metalloproteinase family (MMPs), which degrade collagen fibrils and other components of the dermal extracellular matrix (ECM) (Fisher et al., 1996; Yaar and Gilchrest, 2007). Elevation of MMPs due to chronic sun exposure can promote accumulation of dermal ECM fragmentation, which contrib...
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ژورنال
عنوان ژورنال: Materials Today
سال: 2016
ISSN: 1369-7021
DOI: 10.1016/j.mattod.2016.01.015